A role for human homologous recombination factors in suppressing microhomology-mediated end joining

DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pa...

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書目詳細資料
發表在:Nucleic Acids Res
Main Authors: Ahrabi, Sara, Sarkar, Sovan, Pfister, Sophia X., Pirovano, Giacomo, Higgins, Geoff S., Porter, Andrew C.G., Humphrey, Timothy C.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
主題:
Genome Integrity, Repair and Replication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937322/
https://ncbi.nlm.nih.gov/pubmed/27131361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw326
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