A role for human homologous recombination factors in suppressing microhomology-mediated end joining

DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pa...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Ahrabi, Sara, Sarkar, Sovan, Pfister, Sophia X., Pirovano, Giacomo, Higgins, Geoff S., Porter, Andrew C.G., Humphrey, Timothy C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4937322/
https://ncbi.nlm.nih.gov/pubmed/27131361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw326
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