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A PTCH1 Homolog Transcriptionally Activated by p53 Suppresses Hedgehog Signaling
The p53-mediated responses to DNA damage and the Hedgehog (Hh) signaling pathway are each recurrently dysregulated in many types of human cancer. Here we describe PTCH53, a p53 target gene that is homologous to the tumor suppressor gene PTCH1 and can function as a repressor of Hh pathway activation....
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4239647/ https://ncbi.nlm.nih.gov/pubmed/25296753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597203 |
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