ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance

Angiopoietin-like (ANGPTL)3 and ANGPTL8 are secreted proteins and inhibitors of LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL proteins interact to regulate LPL activity. ANGPTL3 inhibits LPL activity and increases serum TG independent of ANGPTL8. These effects a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Lipid Res
Prif Awduron: Haller, Jorge F., Mintah, Ivory J., Shihanian, Lisa M., Stevis, Panayiotis, Buckler, David, Alexa-Braun, Corey A., Kleiner, Sandra, Banfi, Serena, Cohen, Jonathan C., Hobbs, Helen H., Yancopoulos, George D., Murphy, Andrew J., Gusarova, Viktoria, Gromada, Jesper
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454515/
https://ncbi.nlm.nih.gov/pubmed/28413163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M075689
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