Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for individuals with homozygous familial hypercholesterole...

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Vydáno v:J Lipid Res
Hlavní autoři: Adam, Rene C., Mintah, Ivory J., Alexa-Braun, Corey A., Shihanian, Lisa M., Lee, Joseph S., Banerjee, Poulabi, Hamon, Sara C., Kim, Hye In, Cohen, Jonathan C., Hobbs, Helen H., Van Hout, Cristopher, Gromada, Jesper, Murphy, Andrew J., Yancopoulos, George D., Sleeman, Mark W., Gusarova, Viktoria
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469887/
https://ncbi.nlm.nih.gov/pubmed/32646941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000888
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