Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for individuals with homozygous familial hypercholesterole...

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Detalles Bibliográficos
Publicado en:J Lipid Res
Main Authors: Adam, Rene C., Mintah, Ivory J., Alexa-Braun, Corey A., Shihanian, Lisa M., Lee, Joseph S., Banerjee, Poulabi, Hamon, Sara C., Kim, Hye In, Cohen, Jonathan C., Hobbs, Helen H., Van Hout, Cristopher, Gromada, Jesper, Murphy, Andrew J., Yancopoulos, George D., Sleeman, Mark W., Gusarova, Viktoria
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469887/
https://ncbi.nlm.nih.gov/pubmed/32646941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000888
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