Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for individuals with homozygous familial hypercholesterole...

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Udgivet i:J Lipid Res
Main Authors: Adam, Rene C., Mintah, Ivory J., Alexa-Braun, Corey A., Shihanian, Lisa M., Lee, Joseph S., Banerjee, Poulabi, Hamon, Sara C., Kim, Hye In, Cohen, Jonathan C., Hobbs, Helen H., Van Hout, Cristopher, Gromada, Jesper, Murphy, Andrew J., Yancopoulos, George D., Sleeman, Mark W., Gusarova, Viktoria
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469887/
https://ncbi.nlm.nih.gov/pubmed/32646941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000888
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