ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice

Angiopoietin-like protein (ANGPTL)8 is a negative regulator of lipoprotein lipase–mediated plasma triglyceride (TG) clearance. In this study, we describe a fully human monoclonal antibody (REGN3776) that binds monkey and human ANGPTL8 with high affinity. Inhibition of ANGPTL8 with REGN3776 in humani...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Endocrinology
Κύριοι συγγραφείς: Gusarova, Viktoria, Banfi, Serena, Alexa-Braun, Corey A., Shihanian, Lisa M., Mintah, Ivory J., Lee, Joseph S., Xin, Yurong, Su, Qi, Kamat, Vishal, Cohen, Jonathan C., Hobbs, Helen H., Zambrowicz, Brian, Yancopoulos, George D., Murphy, Andrew J., Gromada, Jesper
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Endocrine Society 2017
Θέματα:
Special Section: Metabolism in Endocrine Health and Disease
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460832/
https://ncbi.nlm.nih.gov/pubmed/28204173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1894
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