ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice

Angiopoietin-like protein (ANGPTL)8 is a negative regulator of lipoprotein lipase–mediated plasma triglyceride (TG) clearance. In this study, we describe a fully human monoclonal antibody (REGN3776) that binds monkey and human ANGPTL8 with high affinity. Inhibition of ANGPTL8 with REGN3776 in humani...

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Dettagli Bibliografici
Pubblicato in:Endocrinology
Autori principali: Gusarova, Viktoria, Banfi, Serena, Alexa-Braun, Corey A., Shihanian, Lisa M., Mintah, Ivory J., Lee, Joseph S., Xin, Yurong, Su, Qi, Kamat, Vishal, Cohen, Jonathan C., Hobbs, Helen H., Zambrowicz, Brian, Yancopoulos, George D., Murphy, Andrew J., Gromada, Jesper
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2017
Soggetti:
Special Section: Metabolism in Endocrine Health and Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460832/
https://ncbi.nlm.nih.gov/pubmed/28204173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1894
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