ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance

Angiopoietin-like (ANGPTL)3 and ANGPTL8 are secreted proteins and inhibitors of LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL proteins interact to regulate LPL activity. ANGPTL3 inhibits LPL activity and increases serum TG independent of ANGPTL8. These effects a...

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Bibliografische gegevens
Gepubliceerd in:J Lipid Res
Hoofdauteurs: Haller, Jorge F., Mintah, Ivory J., Shihanian, Lisa M., Stevis, Panayiotis, Buckler, David, Alexa-Braun, Corey A., Kleiner, Sandra, Banfi, Serena, Cohen, Jonathan C., Hobbs, Helen H., Yancopoulos, George D., Murphy, Andrew J., Gusarova, Viktoria, Gromada, Jesper
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2017
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454515/
https://ncbi.nlm.nih.gov/pubmed/28413163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M075689
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