ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance

Angiopoietin-like (ANGPTL)3 and ANGPTL8 are secreted proteins and inhibitors of LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL proteins interact to regulate LPL activity. ANGPTL3 inhibits LPL activity and increases serum TG independent of ANGPTL8. These effects a...

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Publicado en:J Lipid Res
Autores principales: Haller, Jorge F., Mintah, Ivory J., Shihanian, Lisa M., Stevis, Panayiotis, Buckler, David, Alexa-Braun, Corey A., Kleiner, Sandra, Banfi, Serena, Cohen, Jonathan C., Hobbs, Helen H., Yancopoulos, George D., Murphy, Andrew J., Gusarova, Viktoria, Gromada, Jesper
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454515/
https://ncbi.nlm.nih.gov/pubmed/28413163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M075689
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