ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys(1)

Angiopoietin-like protein 3 (ANGPTL3) is a circulating protein synthesized exclusively in the liver that inhibits LPL and endothelial lipase (EL), enzymes that hydrolyze TGs and phospholipids in plasma lipoproteins. Here we describe the development and testing of a fully human monoclonal antibody (R...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Gusarova, Viktoria, Alexa, Corey A., Wang, Yan, Rafique, Ashique, Kim, Jee Hae, Buckler, David, Mintah, Ivory J., Shihanian, Lisa M., Cohen, Jonathan C., Hobbs, Helen H., Xin, Yurong, Valenzuela, David M., Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479335/
https://ncbi.nlm.nih.gov/pubmed/25964512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M054890
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