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KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

BACKGROUND: Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the dow...

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Bibliografiske detaljer
Main Authors: Pao, William, Wang, Theresa Y, Riely, Gregory J, Miller, Vincent A, Pan, Qiulu, Ladanyi, Marc, Zakowski, Maureen F, Heelan, Robert T, Kris, Mark G, Varmus, Harold E
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545207/
https://ncbi.nlm.nih.gov/pubmed/15696205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0020017
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