KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

BACKGROUND: Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the dow...

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Hauptverfasser: Pao, William, Wang, Theresa Y, Riely, Gregory J, Miller, Vincent A, Pan, Qiulu, Ladanyi, Marc, Zakowski, Maureen F, Heelan, Robert T, Kris, Mark G, Varmus, Harold E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2005
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545207/
https://ncbi.nlm.nih.gov/pubmed/15696205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0020017
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