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KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib
BACKGROUND: Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the dow...
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Main Authors: | , , , , , , , , , |
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格式: | Artigo |
語言: | Inglês |
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Public Library of Science
2005
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在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545207/ https://ncbi.nlm.nih.gov/pubmed/15696205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0020017 |
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