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KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib
BACKGROUND: Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the dow...
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| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science
2005
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545207/ https://ncbi.nlm.nih.gov/pubmed/15696205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0020017 |
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