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KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

BACKGROUND: Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the dow...

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Main Authors: Pao, William, Wang, Theresa Y, Riely, Gregory J, Miller, Vincent A, Pan, Qiulu, Ladanyi, Marc, Zakowski, Maureen F, Heelan, Robert T, Kris, Mark G, Varmus, Harold E
格式: Artigo
語言:Inglês
出版: Public Library of Science 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC545207/
https://ncbi.nlm.nih.gov/pubmed/15696205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0020017
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