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KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

BACKGROUND: Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the dow...

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Publicat a:PLoS Med
Autors principals: Pao, William, Wang, Theresa Y, Riely, Gregory J, Miller, Vincent A, Pan, Qiulu, Ladanyi, Marc, Zakowski, Maureen F, Heelan, Robert T, Kris, Mark G, Varmus, Harold E
Format: Artigo
Idioma:Inglês
Publicat: PLOS 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545207/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15696205/
https://ncbi.nlm.nih.govhttps://doi.org/10.1371/journal.pmed.0020017
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