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EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene are reportedly associated with sensitivity of lung cancers to gefitinib (Iressa), kinase inhibitor. In-frame deletions occur in exon 19, whereas point mutations occur frequently in codon 858 (exo...

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Dettagli Bibliografici
Autori principali: Pao, William, Miller, Vincent, Zakowski, Maureen, Doherty, Jennifer, Politi, Katerina, Sarkaria, Inderpal, Singh, Bhuvanesh, Heelan, Robert, Rusch, Valerie, Fulton, Lucinda, Mardis, Elaine, Kupfer, Doris, Wilson, Richard, Kris, Mark, Varmus, Harold
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC516528/
https://ncbi.nlm.nih.gov/pubmed/15329413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405220101
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