EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene are reportedly associated with sensitivity of lung cancers to gefitinib (Iressa), kinase inhibitor. In-frame deletions occur in exon 19, whereas point mutations occur frequently in codon 858 (exo...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Pao, William, Miller, Vincent, Zakowski, Maureen, Doherty, Jennifer, Politi, Katerina, Sarkaria, Inderpal, Singh, Bhuvanesh, Heelan, Robert, Rusch, Valerie, Fulton, Lucinda, Mardis, Elaine, Kupfer, Doris, Wilson, Richard, Kris, Mark, Varmus, Harold
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2004
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516528/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15329413/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0405220101
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