EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib

Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene are reportedly associated with sensitivity of lung cancers to gefitinib (Iressa), kinase inhibitor. In-frame deletions occur in exon 19, whereas point mutations occur frequently in codon 858 (exo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pao, William, Miller, Vincent, Zakowski, Maureen, Doherty, Jennifer, Politi, Katerina, Sarkaria, Inderpal, Singh, Bhuvanesh, Heelan, Robert, Rusch, Valerie, Fulton, Lucinda, Mardis, Elaine, Kupfer, Doris, Wilson, Richard, Kris, Mark, Varmus, Harold
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516528/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15329413/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0405220101
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