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Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice
BACKGROUND: Polyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar neurodegeneration, and gliosis. Currently, there are no treatments available to...
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| 出版年: | J Neuroinflammation |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5445366/ https://ncbi.nlm.nih.gov/pubmed/28545543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0880-z |
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