Astroglia contribute to the pathogenesis of spinocerebellar ataxia type 1 (SCA1) in a biphasic, stage-of-disease specific manner

Spinocerebellar ataxia type 1 (SCA1) is a fatal, dominantly inherited neurodegenerative disease caused by the expansion of CAG repeats in the Ataxin-1 (ATXN1) gene. SCA1 is characterized by balance and coordination deficits due to the predominant loss of Purkinje neurons in the cerebellum. We previo...

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Vydáno v:Glia
Hlavní autoři: Kim, Joo Hyun, Lukowicz, Abigail, Qu, Wenhui, Johnson, Andrea, Cvetanovic, Marija
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049102/
https://ncbi.nlm.nih.gov/pubmed/30043530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23451
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