Post-symptomatic Delivery of Brain Derived Neurotrophic Factor (BDNF) Ameliorates Spinocerebellar Ataxia Type 1 (SCA1) Pathogenesis

Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an abnormal expansion of CAG repeats in the Ataxin1 (ATXN1) gene. SCA1 is characterized by motor deficits, cerebellar neurodegeneration, gliosis and gene expression changes. Expression of brain derived neurotrophic f...

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Bibliographic Details
Published in:Cerebellum
Main Authors: Sheeler, Carrie, Rosa, Juao-Guilherme, Borgenheimer, Ella, Mellesmoen, Aaron, Rainwater, Orion, Cvetanovic, Marija
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217121/
https://ncbi.nlm.nih.gov/pubmed/33394333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12311-020-01226-3
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