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VEGF ameliorates the ataxic phenotype in spinocerebellar ataxia type 1 (SCA1) mice
SCA1 is an adult-onset, dominantly inherited neurodegenerative disease caused by expansion of a glutamine repeat tract in ATXN1. Although the precise function of ATXN1 remains elusive, it appears to play a role in transcriptional repression. We find that mutant ATXN1 suppresses transcription of the...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287040/ https://ncbi.nlm.nih.gov/pubmed/22001907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2494 |
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