Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice

BACKGROUND: Polyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar neurodegeneration, and gliosis. Currently, there are no treatments available to...

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Gepubliceerd in:J Neuroinflammation
Hoofdauteurs: Qu, Wenhui, Johnson, Andrea, Kim, Joo Hyun, Lukowicz, Abigail, Svedberg, Daniel, Cvetanovic, Marija
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2017
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445366/
https://ncbi.nlm.nih.gov/pubmed/28545543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0880-z
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