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Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia
Notch signaling is considered a rational target in the therapy of several cancers, particularly those harbouring Notch gain of function mutations, including T-cell acute lymphoblastic leukemia (T-ALL). Although currently available Notch-blocking agents are showing anti-tumor activity in preclinical...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5438367/ https://ncbi.nlm.nih.gov/pubmed/28526832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02316-9 |
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