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Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer caused by the deregulation of key T-cell developmental pathways, including Notch signaling. Aberrant Notch signaling in T-ALL occurs by NOTCH1 gain-of-function mutations and by NOTCH3 overexpression. Although NOTCH3 is assumed...
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| Publicat a: | Front Oncol |
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| Autors principals: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6456714/ https://ncbi.nlm.nih.gov/pubmed/31001470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00198 |
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