Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia

[Image: see text] Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound 18...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Quaglio, Deborah, Zhdanovskaya, Nadezda, Tobajas, Gloria, Cuartas, Viviana, Balducci, Silvia, Christodoulou, Michael S., Fabrizi, Giancarlo, Gargantilla, Marta, Priego, Eva-María, Carmona Pestaña, Álvaro, Passarella, Daniele, Screpanti, Isabella, Botta, Bruno, Palermo, Rocco, Mori, Mattia, Ghirga, Francesca, Pérez-Pérez, María-Jesús
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466818/
https://ncbi.nlm.nih.gov/pubmed/30996810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00608
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