Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia

Notch signaling is considered a rational target in the therapy of several cancers, particularly those harbouring Notch gain of function mutations, including T-cell acute lymphoblastic leukemia (T-ALL). Although currently available Notch-blocking agents are showing anti-tumor activity in preclinical...

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Publicat a:Sci Rep
Autors principals: Mori, Mattia, Tottone, Luca, Quaglio, Deborah, Zhdanovskaya, Nadezda, Ingallina, Cinzia, Fusto, Marisa, Ghirga, Francesca, Peruzzi, Giovanna, Crestoni, Maria Elisa, Simeoni, Fabrizio, Giulimondi, Francesca, Talora, Claudio, Botta, Bruno, Screpanti, Isabella, Palermo, Rocco
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438367/
https://ncbi.nlm.nih.gov/pubmed/28526832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02316-9
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