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Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication
Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell proliferation compared with p53-null cancer cells, the mec...
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| 發表在: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Clinical Investigation
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409068/ https://ncbi.nlm.nih.gov/pubmed/28394262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87724 |
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