Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl

p53 mutations are present in up to 70% of lung cancer. Cancer cells with p53 mutations, in general, grow more aggressively than those with wild-type p53 or no p53. Expression of tumor-derived mutant p53 in cells leads to up-regulated expression of genes that may affect cell growth and oncogenesis. I...

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Detalhes bibliográficos
Main Authors: Vaughan, Catherine A., Singh, Shilpa, Windle, Brad, Yeudall, W. Andrew, Frum, Rebecca, Grossman, Steven R., Deb, Swati P., Deb, Sumitra
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527987/
https://ncbi.nlm.nih.gov/pubmed/23264849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912462719
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