Gain‐of‐function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells

Gain‐of‐function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. Here, we report that GOF p53 induces tumorigenicity through simultaneous activation of key oncogenic pathways including those controlling putative tumor‐initiating cell functions. We determined t...

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Detalles Bibliográficos
Publicado en:Mol Oncol
Autores principales: Vaughan, Catherine A., Singh, Shilpa, Grossman, Steven R., Windle, Brad, Deb, Swati Palit, Deb, Sumitra
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467493/
https://ncbi.nlm.nih.gov/pubmed/28423230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12068
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