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Gain‐of‐function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells

Gain‐of‐function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. Here, we report that GOF p53 induces tumorigenicity through simultaneous activation of key oncogenic pathways including those controlling putative tumor‐initiating cell functions. We determined t...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Vaughan, Catherine A., Singh, Shilpa, Grossman, Steven R., Windle, Brad, Deb, Swati Palit, Deb, Sumitra
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467493/
https://ncbi.nlm.nih.gov/pubmed/28423230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12068
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