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Gain‐of‐function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells

Gain‐of‐function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. Here, we report that GOF p53 induces tumorigenicity through simultaneous activation of key oncogenic pathways including those controlling putative tumor‐initiating cell functions. We determined t...

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Dades bibliogràfiques
Publicat a:Mol Oncol
Autors principals: Vaughan, Catherine A., Singh, Shilpa, Grossman, Steven R., Windle, Brad, Deb, Swati Palit, Deb, Sumitra
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467493/
https://ncbi.nlm.nih.gov/pubmed/28423230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12068
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