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Gain‐of‐function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells
Gain‐of‐function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. Here, we report that GOF p53 induces tumorigenicity through simultaneous activation of key oncogenic pathways including those controlling putative tumor‐initiating cell functions. We determined t...
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| Publicado no: | Mol Oncol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5467493/ https://ncbi.nlm.nih.gov/pubmed/28423230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12068 |
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