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The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
p53 mutations with single amino acid changes in cancer often lead to dominant oncogenic changes. Here, we have developed a mouse model of gain-of-function (GOF) p53-driven lung cancer utilizing conditionally active LSL p53-R172H and LSL K-Ras-G12D knock-in alleles that can be activated by Cre in lun...
Enregistré dans:
| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7846773/ https://ncbi.nlm.nih.gov/pubmed/33514736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20928-8 |
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