The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3

p53 mutations with single amino acid changes in cancer often lead to dominant oncogenic changes. Here, we have developed a mouse model of gain-of-function (GOF) p53-driven lung cancer utilizing conditionally active LSL p53-R172H and LSL K-Ras-G12D knock-in alleles that can be activated by Cre in lun...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Vaughan, Catherine A., Singh, Shilpa, Subler, Mark A., Windle, Jolene J., Inoue, Kazushi, Fry, Elizabeth A., Pillappa, Raghavendra, Grossman, Steven R., Windle, Brad, Andrew Yeudall, W., Deb, Swati Palit, Deb, Sumitra
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846773/
https://ncbi.nlm.nih.gov/pubmed/33514736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20928-8
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