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Allele specific gain-of-function activity of p53 mutants in lung cancer cells
p53 mutations are mostly single amino acid changes resulting in expression of a stable mutant protein with “gain of function” (GOF) activity having a dominant oncogenic role rather than simple loss of function of wild-type p53. Knock-down of mutant p53 in human lung cancer cell lines with different...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731231/ https://ncbi.nlm.nih.gov/pubmed/22989750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.09.029 |
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