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Allele specific gain-of-function activity of p53 mutants in lung cancer cells

p53 mutations are mostly single amino acid changes resulting in expression of a stable mutant protein with “gain of function” (GOF) activity having a dominant oncogenic role rather than simple loss of function of wild-type p53. Knock-down of mutant p53 in human lung cancer cell lines with different...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochem Biophys Res Commun
Main Authors: Vaughan, Catherine A, Frum, Rebecca, Pearsall, Isabella, Singh, Shilpa, Windle, Brad, Yeudall, Andrew, Deb, Swati P., Deb, Sumitra
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731231/
https://ncbi.nlm.nih.gov/pubmed/22989750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.09.029
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