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Allele specific gain-of-function activity of p53 mutants in lung cancer cells
p53 mutations are mostly single amino acid changes resulting in expression of a stable mutant protein with “gain of function” (GOF) activity having a dominant oncogenic role rather than simple loss of function of wild-type p53. Knock-down of mutant p53 in human lung cancer cell lines with different...
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出版年: | Biochem Biophys Res Commun |
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主要な著者: | , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2012
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731231/ https://ncbi.nlm.nih.gov/pubmed/22989750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.09.029 |
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