p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity

Cancer cells with p53 mutations, in general, grow more aggressively than those with wild-type p53 and show “gain of function”(GOF) phenotypes such as increased growth rate, enhanced resistance to chemotherapeutic drugs, increased cell motility and tumorigenicity; although the mechanism for this func...

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Detalhes bibliográficos
Main Authors: Vaughan, Catherine A, Singh, Shilpa, Windle, Brad, Sankala, Heidi M, Graves, Paul R., Yeudall, W. Andrew, Deb, Swati P., Deb, Sumitra
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272778/
https://ncbi.nlm.nih.gov/pubmed/22198284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.12.006
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