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p53 mutants induce transcription of NF-κB2 in H1299 cells through CBP and STAT binding on the NF-κB2 promoter and gain of function activity
Cancer cells with p53 mutations, in general, grow more aggressively than those with wild-type p53 and show “gain of function”(GOF) phenotypes such as increased growth rate, enhanced resistance to chemotherapeutic drugs, increased cell motility and tumorigenicity; although the mechanism for this func...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272778/ https://ncbi.nlm.nih.gov/pubmed/22198284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2011.12.006 |
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