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Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication

Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell proliferation compared with p53-null cancer cells, the mec...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Singh, Shilpa, Vaughan, Catherine A., Frum, Rebecca A., Grossman, Steven R., Deb, Sumitra, Palit Deb, Swati
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409068/
https://ncbi.nlm.nih.gov/pubmed/28394262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87724
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