Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication

Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell proliferation compared with p53-null cancer cells, the mec...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Singh, Shilpa, Vaughan, Catherine A., Frum, Rebecca A., Grossman, Steven R., Deb, Sumitra, Palit Deb, Swati
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409068/
https://ncbi.nlm.nih.gov/pubmed/28394262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87724
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