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Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication
Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell proliferation compared with p53-null cancer cells, the mec...
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| Izdano u: | J Clin Invest |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409068/ https://ncbi.nlm.nih.gov/pubmed/28394262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87724 |
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