Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication

Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell proliferation compared with p53-null cancer cells, the mec...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Singh, Shilpa, Vaughan, Catherine A., Frum, Rebecca A., Grossman, Steven R., Deb, Sumitra, Palit Deb, Swati
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409068/
https://ncbi.nlm.nih.gov/pubmed/28394262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87724
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