Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure

Cigarette smoking (CS), the main risk factor for COPD (chronic obstructive pulmonary disease) in developed countries, decreases alveolar macrophages (AM) clearance of both apoptotic cells and bacterial pathogens. This global deficit of AM engulfment may explain why active smokers have worse outcomes...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Serban, Karina A., Petrusca, Daniela N., Mikosz, Andrew, Poirier, Christophe, Lockett, Angelia D., Saint, Lauren, Justice, Matthew J., Twigg, Homer L., Campos, Michael A., Petrache, Irina
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407578/
https://ncbi.nlm.nih.gov/pubmed/28448535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176073
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