Effect of Cigarette Smoke Exposure and Structural Modifications on the α-1 Antitrypsin Interaction with Caspases

α-1 Antitrypsin (A1AT) is a serpin with a major protective effect against cigarette smoke–induced emphysema development, and patients with mutations of the A1AT gene display a markedly increased risk for developing emphysema. We reported that A1AT protects lung endothelial cells from apoptosis and i...

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Huvudupphovsmän: Lockett, Angelia D, Van Demark, Mary, Gu, Yuan, Schweitzer, Kelly S, Sigua, Ninotchka, Kamocki, Krzysztof, Fijalkowska, Iwona, Garrison, Jana, Fisher, Amanda J, Serban, Karina, Wise, Robert A, Flotte, Terence R, Mueller, Christian, Presson, Robert G, Petrache, Horia I, Tuder, Rubin M, Petrache, Irina
Materialtyp: Artigo
Språk:Inglês
Publicerad: ScholarOne 2012
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356416/
https://ncbi.nlm.nih.gov/pubmed/22245800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00207
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