α-1 Antitrypsin Inhibits Caspase-3 Activity, Preventing Lung Endothelial Cell Apoptosis

α-1 Antitrypsin (A1AT) is an abundant circulating serpin with a postulated function in the lung of potently inhibiting neutrophil-derived proteases. Emphysema attributable to A1AT deficiency led to the concept that a protease/anti-protease imbalance mediates cigarette smoke-induced emphysema. We hyp...

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Main Authors: Petrache, Irina, Fijalkowska, Iwona, Medler, Terry R., Skirball, Jarrett, Cruz, Pedro, Zhen, Lijie, Petrache, Horia I., Flotte, Terence R., Tuder, Rubin M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1780181/
https://ncbi.nlm.nih.gov/pubmed/17003475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060058
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