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Ceramide upregulation causes pulmonary cell apoptosis and emphysema
Alveolar cell apoptosis is involved in the pathogenesis of emphysema, a prevalent disease primarily caused by cigarette smoking. We report that ceramide, a second messenger lipid, is a critical mediator of alveolar destruction in emphysema. Inhibition of enzymes controlling de novo ceramide synthesi...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1352344/ https://ncbi.nlm.nih.gov/pubmed/15852018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1238 |
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