Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide

The molecular events leading to emphysema development include generation of oxidative stress and alveolar cell apoptosis. Oxidative stress upregulates ceramides, proapoptotic signaling sphingolipids that trigger further oxidative stress and alveolar space enlargement, as shown in an experimental mod...

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Detalhes bibliográficos
Main Authors: Petrache, Irina, Medler, Terry R., Richter, Amy T., Kamocki, Krzysztof, Chukwueke, Ugonma, Zhen, Lijie, Gu, Yuan, Adamowicz, Jeremy, Schweitzer, Kelly S., Hubbard, Walter C., Berdyshev, Evgeny V., Lungarella, Giuseppe, Tuder, Rubin M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494787/
https://ncbi.nlm.nih.gov/pubmed/18441093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00448.2007
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