Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide

The molecular events leading to emphysema development include generation of oxidative stress and alveolar cell apoptosis. Oxidative stress upregulates ceramides, proapoptotic signaling sphingolipids that trigger further oxidative stress and alveolar space enlargement, as shown in an experimental mod...

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Autores principales: Petrache, Irina, Medler, Terry R., Richter, Amy T., Kamocki, Krzysztof, Chukwueke, Ugonma, Zhen, Lijie, Gu, Yuan, Adamowicz, Jeremy, Schweitzer, Kelly S., Hubbard, Walter C., Berdyshev, Evgeny V., Lungarella, Giuseppe, Tuder, Rubin M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2008
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494787/
https://ncbi.nlm.nih.gov/pubmed/18441093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00448.2007
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