Stimulation of Sphingosine 1-Phosphate Signaling as an Alveolar Cell Survival Strategy in Emphysema

Rationale: Vascular endothelial growth factor receptor (VEGFR) inhibition increases ceramides in lung structural cells of the alveolus, initiating apoptosis and alveolar destruction morphologically resembling emphysema. The effects of increased endogenous ceramides could be offset by sphingosine 1-p...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Diab, Khalil J., Adamowicz, Jeremy J., Kamocki, Krzysztof, Rush, Natalia I., Garrison, Jana, Gu, Yuan, Schweitzer, Kelly S., Skobeleva, Anastasia, Rajashekhar, Gangaraju, Hubbard, Walter C., Berdyshev, Evgeny V., Petrache, Irina
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2010
Assuntos:
C. Chronic Obstructive Pulmonary Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455841/
https://ncbi.nlm.nih.gov/pubmed/19965812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200906-0826OC
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