Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate

Sphingosine kinase 1 (SK1) produces sphingosine-1-phosphate (S1P), a potent signaling lipid. The subcellular localization of SK1 can dictate its signaling function. Here, we use artificial targeting of SK1 to either the plasma membrane (PM) or the endoplasmic reticulum (ER) to test the effects of co...

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Hlavní autoři: Siow, Deanna L., Anderson, Charles D., Berdyshev, Evgeny V., Skobeleva, Anastasia, Pitson, Stuart M., Wattenberg, Binks W.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2010
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918438/
https://ncbi.nlm.nih.gov/pubmed/20386061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M004374
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