Stimulation of Sphingosine 1-Phosphate Signaling as an Alveolar Cell Survival Strategy in Emphysema

Rationale: Vascular endothelial growth factor receptor (VEGFR) inhibition increases ceramides in lung structural cells of the alveolus, initiating apoptosis and alveolar destruction morphologically resembling emphysema. The effects of increased endogenous ceramides could be offset by sphingosine 1-p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Respir Crit Care Med
Prif Awduron: Diab, Khalil J., Adamowicz, Jeremy J., Kamocki, Krzysztof, Rush, Natalia I., Garrison, Jana, Gu, Yuan, Schweitzer, Kelly S., Skobeleva, Anastasia, Rajashekhar, Gangaraju, Hubbard, Walter C., Berdyshev, Evgeny V., Petrache, Irina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Thoracic Society 2010
Pynciau:
C. Chronic Obstructive Pulmonary Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455841/
https://ncbi.nlm.nih.gov/pubmed/19965812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200906-0826OC
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