Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium

The homeostatic lung protective effects of alpha-1 antitrypsin (A1AT) may require the transport of circulating proteinase inhibitor across an intact lung endothelial barrier. We hypothesized that uninjured pulmonary endothelial cells transport A1AT to lung epithelial cells. Purified human A1AT was r...

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Autori principali: Lockett, Angelia D., Brown, Mary Beth, Santos-Falcon, Nieves, Rush, Natalia I., Oueini, Houssam, Oberle, Amber J., Bolanis, Esther, Fragoso, Miryam A., Petrusca, Daniela N., Serban, Karina A., Schweitzer, Kelly S., Presson Jr., Robert G., Campos, Michael, Petrache, Irina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990572/
https://ncbi.nlm.nih.gov/pubmed/24743137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093979
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