ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

BACKGROUND: Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether ANGPTL3 deficiency reduces risk of coronary artery disease (CAD) is unknow...

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Pubblicato in:J Am Coll Cardiol
Autori principali: Stitziel, Nathan O., Khera, Amit V., Wang, Xiao, Bierhals, Andrew J., Vourakis, A. Christina, Sperry, Alexandra E., Natarajan, Pradeep, Klarin, Derek, Emdin, Connor A., Zekavat, Seyedeh M., Nomura, Akihiro, Erdmann, Jeanette, Schunkert, Heribert, Samani, Nilesh J., Kraus, William E., Shah, Svati H., Yu, Bing, Boerwinkle, Eric, Rader, Daniel J., Gupta, Namrata, Frossard, Philippe M., Rasheed, Asif, Danesh, John, Lander, Eric S., Gabriel, Stacey, Saleheen, Danish, Musunuru, Kiran, Kathiresan, Sekar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404817/
https://ncbi.nlm.nih.gov/pubmed/28385496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2017.02.030
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