Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

BACKGROUND: Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk factor for coronary heart disease (CHD). As such, lowering Lp(a) has emerged as a therapeutic strategy. Beyond target identification, human genetics may...

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Detalhes bibliográficos
Publicado no:J Am Coll Cardiol
Main Authors: Emdin, Connor A., Khera, Amit V., Natarajan, Pradeep, Klarin, Derek, Won, Hong-Hee, Peloso, Gina M., Stitziel, Nathan O., Nomura, Akihiro, Zekavat, Seyedeh M., Bick, Alexander G., Gupta, Namrata, Asselta, Rosanna, Duga, Stefano, Merlini, Piera Angelica, Correa, Adolfo, Kessler, Thorsten, Wilson, James G., Bown, Matthew J., Hall, Alistair S., Braund, Peter S., Samani, Nilesh J., Schunkert, Heribert, Marrugat, Jaume, Elosua, Roberto, McPherson, Ruth, Farrall, Martin, Watkins, Hugh, Willer, Cristen, Abecasis, Gonçalo R., Felix, Janine F., Vasan, Ramachandran S., Lander, Eric, Rader, Daniel J., Danesh, John, Ardissino, Diego, Gabriel, Stacey, Saleheen, Danish, Kathiresan, Sekar
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328146/
https://ncbi.nlm.nih.gov/pubmed/28007139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2016.10.033
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