Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

BACKGROUND: Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk factor for coronary heart disease (CHD). As such, lowering Lp(a) has emerged as a therapeutic strategy. Beyond target identification, human genetics may...

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Bibliografiska uppgifter
I publikationen:J Am Coll Cardiol
Huvudupphovsmän: Emdin, Connor A., Khera, Amit V., Natarajan, Pradeep, Klarin, Derek, Won, Hong-Hee, Peloso, Gina M., Stitziel, Nathan O., Nomura, Akihiro, Zekavat, Seyedeh M., Bick, Alexander G., Gupta, Namrata, Asselta, Rosanna, Duga, Stefano, Merlini, Piera Angelica, Correa, Adolfo, Kessler, Thorsten, Wilson, James G., Bown, Matthew J., Hall, Alistair S., Braund, Peter S., Samani, Nilesh J., Schunkert, Heribert, Marrugat, Jaume, Elosua, Roberto, McPherson, Ruth, Farrall, Martin, Watkins, Hugh, Willer, Cristen, Abecasis, Gonçalo R., Felix, Janine F., Vasan, Ramachandran S., Lander, Eric, Rader, Daniel J., Danesh, John, Ardissino, Diego, Gabriel, Stacey, Saleheen, Danish, Kathiresan, Sekar
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328146/
https://ncbi.nlm.nih.gov/pubmed/28007139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2016.10.033
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