DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes

A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type 2 diabetes. We conducted an exome-wide association study of coding variation in UK Biobank (405,569 individuals) to identify variants that l...

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Pubblicato in:Diabetes
Autori principali: Emdin, Connor A., Khera, Amit V., Aragam, Krishna, Haas, Mary, Chaffin, Mark, Klarin, Derek, Natarajan, Pradeep, Bick, Alexander, Zekavat, Seyedeh M., Nomura, Akihiro, Ardissino, Diego, Wilson, James G., Schunkert, Heribert, McPherson, Ruth, Watkins, Hugh, Elosua, Roberto, Bown, Matthew J., Samani, Nilesh J., Baber, Usman, Erdmann, Jeanette, Gupta, Namrata, Danesh, John, Saleheen, Danish, Gabriel, Stacey, Kathiresan, Sekar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2019
Soggetti:
Genetics/Genomes/Proteomics/Metabolomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302541/
https://ncbi.nlm.nih.gov/pubmed/30389748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0857
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